PHARMAKINETICS :DISTRIBUTION AND ELLIMINATION OF DRUGS IN THE BODY

tHE MEDICINE OR DRUGS CAN BE ADMINISTERED  IN DIFFERENT ROUTES : THE FASTEST IS THE I.V THE INTRAVENOUS ROUTES

....IN SECONDS YOU CAN HAVE THE DESIRED EFFECT OF THE DRUG... AND THE SLOWEST IS THE ORAL ROUTES....IT TAKES 30 MINUTES TO 1 HOUR TO GET THE DESIRED EFFECT....

LETS GO TO THE PROCESS HOW DRUGS BEEN USED BY THE BODY.....SO LETS TAKE THE INTRAVENOUS ROUTE SINCE THIS IS THE ONE USED IN MICHAEL`S CASE.......SO THE DRUG IS INJECTED INTO THE VEINS OF MICHAEL....SO THE  DRUG MIXED WITH THE BLOOD  TRANSPORTED BACK TO THE HEART ......THE BLOOD NOW THAT CARRYING THE DRUG  PUMPED OUT OF THE HEART TO BE DISTRIBUTED THROUGHOUT THE BODY.....NOW THE DRUG CARRIED BY THE BLOOD HAS ITS OWN AFFINITY TO A CERTAIN TISSUES.....PROPOFOL HAS THE CHARACTERISTIC FITTED FOR THE BRAIN TISSUES.....SO THE BLOOD UNLOADED THE DRUG IN TO THE BRAIN THE BRAIN CONSUMES THE DRUG....THEREFORE IT GIVES THE EXPECTED EFFECT OF THE DRUG.......THE USED PROPOFOL CARRIED BY THE BLOOD OUT OF THE BRAIN TO BE BROUGHT TO THE LIVER FOR BIOTRANSFORMATION TO PRODUCE METABOLITES FOR ELLIMINATION

THE METABOLITES ARE CARRIED BY THE BLOOD OUT OF THE LIVER TRANSPORTED TO THE KIDNEY FOR ELLIMINATION.....WITHDRAWN OUT OF THE BODY THROUGH URINE.....

YOU WILL ASK THEN WHAT IS THE IMPORTANCE OF THIS ILLUSTRATION.....the used drug taken out of the brain and brought to the liver  for biotransformation is the half life of the drug...this is the time the drug efficacy goes down......so if there is remain drug in the body it has no capacity to ellicit the expected effect of the drug......so the doctor have to give another dose of the drug used to maintain the expected effect of the drug........what is the application of this to the testimonies of da walgren and murray......da walgren says that murray given diprivan first and then given a sedative that killed michael.....basing it in the phamakinetics.....the statement of da walgren is not true because the sedatives are only found in the blood  based on the toxicology report it did not reach the liver  it means  that the sedative was not  consumed by the body of michael when it was given........IN MURRAY TESTIMONIES IS ALSO NOT TRUE BECAUSE HE SAYS THAT HE GAVE SEDATIVES ALONE WITHOUT DIPRIVAN  BUT THE TOXICOLOGY REPORT SAYS THAT THE ONLY DRUG FOUND IN THE URINE IS PROPOFOL(DIPRIVAN) AND LIDOCAINE...IT MEANS MURRAY NEVER GIVEN ANY SEDATIVES ON JUNE 25, 2009 BECAUSE MICHAEL WAS ALREADY DEAD ON AT 8PM JUNE 24,2009.....THIS WAS AFFIRMED BY THE TESTIMONY OF THE PARAMEDICS AND DR.COOPER THAT MICHAEL IS COLD AND STIFF WHICH BASED ON POSTMORTEM CHANGES MICHAEL IS DEAD  FOR 8-36 HOURS............I HOPE THE DOCTORS THAT WILL TESTIFY FOR THE JACKSON FAMILY WILL ILLUSTRATE THIS MORE FURTHER TO MAKE THE JURORS CLEARLY THAT MICHAEL WAS KILLED WITHOUT DOUBT ON JUNE 24,2009 NOT JUNE 25, 2009.........